Diltiazem hdrochoride
Diltiazem hdrochoride
CLINICAL USE
Analgesia
DOSE IN NORMAL RENAL FUNCTION
Oral: 30 mg every 4–6 hrsSC/IM: up to 50 mg every 4–6 hrs
PHARMACOKINETICS
Molecular weight                           :451.5 %Protein binding                           :No data %Excreted unchanged in urine     : 13–22 Volume of distribution (L/kg)       :1.1half-life – normal/ESRD (hrs)      :3.5–5/>6 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Use small doses and titrate to response <10           : Use small doses and titrate to response DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min HD                     :Unknown dialysability. Dose as in GFR <10 mL/min HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min CAV/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsNone known ADMINISTRATION
Reconstition
– Route
Oral, IM, SC Rate of Administration
–Comments
– OTHER INFORMATION
Increased and prolonged effect in renal impairment, enhancing respiratory depression and constipationIncreased CNS sensitivity in renal impairment. Accumulation of active metabolites can occur – cautionEffects can be reversed by naloxone dihydrocodeine tartrate.
See how to identify renal failure stages according to GFR calculation
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